Radiation detector calibration

ABSTRACT

A computer program product, method, system and device that acquires, by a radiation detector, exit radiation measurement information during delivery of patient treatment. Patient anatomy information is also received and a radiation detector response calibration is determined utilizing at least the exit radiation measurement information, the patient anatomy information, and at least a portion of a radiation treatment plan.

TECHNICAL FIELD

Radiation therapy quality assurance utilizing radiation detectors.

BACKGROUND

Radiation therapy is used to treat cancerous tumors with ionizing radiation that kills the affected cancer cells. External beam radiotherapy is one method for delivering the ionizing radiation. In such therapy, a patient is placed on a couch and a radiotherapy beam generator (for example, a linear accelerator) is positioned to direct the ionizing radiation at the patient's tumor. One method for determining the proper positioning of the patient with respect to the beam is to use data from a radiation detector, for example an electronic portal imaging device (EPID). Images from an EPID depict the radiation exiting the patient, essentially providing an x-ray image that can be used to properly locate the patient with respect to the beam. Some modern EPID devices use a phosphor and an array of photosensors to detect radiation exiting the patient. Light from the phosphor is converted to an electrical signal and read by a computer to generate a mapping of the radiation pattern striking the phosphor.

SUMMARY

In one aspect, a radiation treatment plan and patient anatomy information is received. During delivery of patient treatment, exit radiation measurement information is acquired by a radiation detector. Utilizing at least the exit radiation measurement information, the patient anatomy information and at least a portion of the radiation treatment plan, a radiation detector response calibration is determined.

In some variations one or more of the following features can optionally be included in any feasible combination.

In one interrelated aspect, determining the radiation detector response calibration can further include determining a patient entrance fluence during a period of time when the exit radiation measurement information was acquired. Utilizing the patient entrance fluence and the patient anatomy information, the patient exit fluence can be determined. The patient exit fluence can be associated with at least a portion of the exit radiation measurement information to arrive at the radiation detector response calibration.

In another interrelated aspect, associating the patient exit fluence with the exit radiation measurement information can further include analyzing the heterogeneities inside the patient, and at least part of the radiation plan, to find a subset of the exit radiation measurement information for creating a list of suitable points to be used for arriving at the radiation detector response calibration. A grouping can be formed from the list of suitable points to arrive at a radiation detector response calibration for each grouping.

In yet another interrelated aspect, the operations determining the patient entrance fluence can also include determining an image start time and an image end time, where the image start time and image end time define the period of time when an image was acquired. The patient entrance fluence can be determined utilizing the at least a portion of the radiation treatment plan and the image start time and image end time.

In another interrelated aspect, the operations determining the image start time and the image end time can include determining estimated collimator profiles from at least a portion of the radiation treatment plan. The estimated collimator profiles can be compared to a measured collimator profile acquired by the radiation detector. The image start time and image end time can be determined from the best match between the estimated collimator profiles and the measured collimator profile.

In a further interrelated aspect, a difference between the measured collimator profile and the best matched estimated collimator profile can be determined. In an effort to arrive at a more accurate image start time and image end time, a range of possible times for the image start time and the image end time used to determine the estimated collimator profiles can be increased if the difference exceeds a predetermined value.

In yet another interrelated aspect, the radiation detector can be an electronic portal imaging device.

Implementations of the current subject matter can include, but are not limited to, methods consistent with the descriptions provided herein as well as articles that comprise a tangibly embodied machine-readable medium operable to cause one or more machines (e.g., computers, etc.) to result in operations implementing one or more of the described features. Similarly, computer systems are also described that may include one or more processors and one or more memories coupled to the one or more processors. A memory, which can include a computer-readable storage medium, may include, encode, store or the like one or more programs that cause one or more processors to perform one or more of the operations described herein. Computer implemented methods consistent with one or more implementations of the current subject matter can be implemented by one or more data processors residing in a single computing system or multiple computing systems. Such multiple computing systems can be connected and can exchange data and/or commands or other instructions or the like via one or more connections, including but not limited to a connection over a network (e.g. the Internet, a wireless wide area network, a local area network, a wide area network, a wired network or the like), via a direct connection between one or more of the multiple computing systems, etc.

The details of one or more variations of the subject matter described herein are set forth in the accompanying drawings and the description below. Other features and advantages of the subject matter described herein will be apparent from the description and drawings and from the claims. While certain features of the currently disclosed subject matter are described for illustrative purposes, it should be readily understood that such features are not intended to be limiting. The claims that follow this disclosure are intended to define the scope of the protected subject matter.

DESCRIPTION OF DRAWINGS

The accompanying drawings, which are incorporated in and constitute a part of this specification, show certain aspects of the subject matter disclosed herein and, together with the description, help explain some of the principles associated with the disclosed implementations. In the drawings,

FIG. 1 is a simplified diagram illustrating a radiation therapy device equipped with a radiation detector for measuring radiation exiting from a patient;

FIG. 2 is a process flow diagram illustrating an exemplary process for the determination of a radiation detector response calibration based on exit radiation measurement information, patient anatomy information and a portion of a radiation treatment plan;

FIG. 3 is a process flow diagram illustrating an exemplary process for determining a radiation detector response calibration utilizing patient exit fluence and exit radiation measurement information;

FIG. 4 is a process flow diagram illustrating an exemplary process for determining patient entrance fluence; and

FIG. 5 is a diagram illustrating an exemplary manner of searching for pairs of control points that may provide an image start time and image end time.

When practical, similar reference numbers denote similar structures, features or elements.

DETAILED DESCRIPTION

The current subject matter is directed to methods, systems, software and apparatus for calibrating a radiation detector. A radiation detector can detect radiation from a radiation therapy device as it exits a patient. This can be used for positioning the patient, but also for radiation therapy quality assurance.

If an accurate calibration of a radiation detector device is available, radiation detector output can be converted to an estimation of dose, and used for radiation therapy quality assurance. As used herein, the term “dose” can refer to any radiation measurement quantity, or combination of quantities, which provide an estimate of the dose or fluence. When a radiation detector is able to measure the radiation that has been transmitted through a patient during treatment, this information can be used with patient anatomy information to determine whether the radiation treatment plan was delivered as intended.

One exemplary embodiment described herein relates to the radiation detector being an EPID device, however, the radiation detector can be any type of radiation detector. For example, the radiation detector could be a device that directly uses diodes without a phosphor.

FIG. 1 illustrates an exemplary radiation therapy device 110 equipped with a radiation detector 180 for measuring the radiation exiting from a patient 130. The radiation therapy device 110 can include a gantry 140 that can rotate about the patient 130. Inside gantry 140, there is a radiation source, for example, a linear accelerator (LINAC), cobalt 60 source, etc., that directs radiation toward patient 130 in the form of treatment beam 150. The treatment beam 150 can also include scanning beams, where a small beamlet is scanned over the area that is required to be treated. The treatment beam 150 may be shaped by a collimator 160, for example, a multi-leaf collimator (MLC), before reaching patient 130. In the example of the collimator 160 being a MLC, the collimation may block part of treatment beam 150 by providing a series of narrow gaps between opposite leaves of the MLC, which combine across multiple leaf pairs to form a desired shape, typically similar to the tumor that is being irradiated. The example of a multi-leaf collimator is used herein; however present disclosure contemplates any type of collimation device.

The treatment of patient 130 can be controlled by a radiation therapy control system 170, which can include, for example, processors, computers, hardware, computer programs, etc., that control the administration of a radiation treatment plan 196 for the patient 130. The radiation therapy control system 170 can control, for example, treatment beam 150, position of gantry 140, beam shape created by collimators 160, etc.

Radiation treatment plans, as used herein, can include any type of information about radiation delivery, such as a treatment plan, obtained in any manner, for example, delivery log information, or any measurements or other data that can provide information about the patient entrance fluence, etc. Typical radiation treatment plans further involve defining specific machine parameters at precise, and typically fine, time intervals to most closely deliver the specified dose of radiation to the target volume in the patient 130. Common parameters used in radiation treatment plans can include, for example, treatment beam shape or energy, orientation of the gantry, collimator leaf positions, patient anatomy (CT) image orientation with respect to the treatment beam, etc.

The patient 130 can rest on patient couch 132 during treatment. After radiation passes through patient 130 and, at times, patient couch 132, the radiation can impact radiation detector 180. In most implementations, radiation detector 180 is connected to gantry 140 or otherwise made to rotate with gantry 140.

Radiation impacting the radiation detector 180 may be detected as a pattern related to the transmission and absorption of the radiation by the patient anatomy and/or tumor(s). Radiation detector 180 may convert the incident radiation to other wavelengths of light, via a phosphor layer (not shown) in radiation detector 180. Light from the phosphor may then be detected by photosensors (not shown) and converted into an electrical signal, essentially creating a pixel map for the radiation incident on radiation detector 180. The electrical signals from radiation detector 180 can be acquired by, for example, analog-to-digital convertors, digitizers, etc. to acquire, filter, analyze, store or otherwise process the acquired exit radiation measurement information.

As part of the monitoring and quality assurance of radiotherapy treatment, systems and diagnostics can be used to estimate the dose delivered to the patient 130 and compare it to the goals specified by the radiation treatment plan. Such systems or software can be integrated into the radiotherapy control system or may be part of a separate quality assurance (QA) computer 190 (as shown in FIG. 1). While the embodiment described herein utilizes a separate quality assurance computer, the present disclosure contemplates the concepts disclosed herein being implemented within the radiation therapy device's control system or any other related system. Though FIG. 1 shows the QA computer 190 and the radiation therapy control system 170 as separate components, the functionality described herein can be performed on an integrated system or distributed across any number or type of hardware or software components that enable the specified functions herein to be performed.

In one implementation, there can be a radiation detector calibration program (not shown) that performs calibration of radiation detector 180 as described herein. The radiation detector can be executed by a QA computer 190, with a radiation therapy control system 170 or on any other computer or processor connected to radiation therapy device 110. In other implementations, the radiation detector calibration program can be stored and/or executed on an independent computer. The data that the radiation detector calibration program requires to perform the radiation detector calibration, for example, radiation detector output 192, patient data 194, a radiation treatment plan 196, etc. can be received by the radiation detector calibration program and executed on the computer running the radiation detector calibration program. The output of the radiation detector calibration program can be loaded and/or stored onto any connected computing system. The connections between any of the systems described herein can be wired, wireless or any combination thereof.

FIG. 2 is a process flow diagram illustrating an exemplary process for determination of a radiation detector response calibration based on exit radiation measurement information, patient anatomy information and at least a portion of a radiation treatment plan. At 200, a radiation treatment plan can be received. At 210, patient treatment can be delivered according to radiation treatment plan 196. At 220, during patient treatment, exit radiation measurement information can be acquired that characterizes the radiation striking radiation detector 180. At 230, patient anatomy information 194 can be received that details the physiological structure of patient 130. Patient anatomy information 194 can include CAT scans, MRI scans, CT scans, radiotherapy structure sets with density overrides, or any other types of patient anatomy information. Patient anatomy information 194 may be acquired before, during or after treatment. At 240, a radiation detector response calibration can be determined utilizing at least a portion of radiation treatment plan 196, treatment delivery logs, measured entrance fluence that was measured before, during, or after the treatment, or the exit radiation measurement information and the patient anatomy information 194.

The radiation detector response calibration can convert the output of the radiation detector, such as an EPID, to a quantity useful for quality assurance purposes such as fluence, dose received by the radiation detector, etc. In one implementation, the radiation detector response calibration can relate the measured signal of the radiation detector to a calculated dose to the patient based on patient anatomy information 194 and at least a portion of the radiation treatment plan 196. The radiation detector response calibration can also be used in order to calculate an expected or predicted exit dose/fluence image for a patient using the radiation treatment plan and the patient anatomy information. The radiation treatment plan and patient anatomy information can serve as a baseline to compare against the measurements acquired during the actual treatment delivery for the purpose of verifying the quality of the treatment delivery to the patient.

Any of the information or data described herein can be received by and/or processed on, for example, QA computer 190, radiation therapy control system 170, other connected or networked computing systems, etc. Similarly, the radiation detector response calibration can be computed, processed or stored by or on any combination of connected computing systems.

The present disclosure's capability of performing radiation detector calibration on an ongoing basis, for example, during patient treatments, relieves the practitioner from dedicating downtime for the radiation therapy device in order to calibrate the device with a phantom. While the present implementation relieves the practitioner of the need to use phantoms, should it be desired to perform the calibration with a phantom, an anthropomorphic or other heterogeneous phantom, non-spherical homogenous phantoms, or homogenous spherically symmetric phantoms placed asymmetrically with respect to the machine isocenter on the treatment couch, the calibration method described herein can be applied in such a manner.

FIG. 3 is a process flow diagram further illustrating an exemplary process for determining a radiation detector response calibration. In discussing a particular embodiment, the present disclosure refers to “images,” “start image,” and “end image.” Such terms are not intended to limit the types of radiation detectors contemplated to those providing images. Use of these terms contemplates that such includes any type of radiation detector output, for example, data sets or other output that can be expressed as a visual image or any other representation of the radiation detected at the radiation detector. At 300, patient entrance fluence, during the period of time when an image was acquired, can be determined. The determination of patient entrance fluence can be, for example, based on dosimeter measurements, beam profile/output monitor measurements, gantry position measurements, collimator position measurements, the radiation treatment plan 196, other entrance fluence/dose measurement devices, etc. At 310, patient exit fluence, or the dose received by each pixel of the radiation detector, can be calculated utilizing the patient entrance fluence and patient anatomy information 194, for example, by using simple approximations such as TERMA calculations or with more accurate dose calculation algorithms such as convolution superposition, Monte Carlo or linear Boltzmann transport equation solvers, artificial neural networks, or the like. Patient exit fluence can further be dose to the radiation detector, scattered radiation measurements, or any other approximation of radiation exiting the patient. For example, the patient exit fluence can include the fluence exiting the patient 130 after the impinging radiation is absorbed and/or scattered by the physical structure of the patient 130. At 320, the patient exit fluence can be associated with at least a portion of the exit radiation measurement information to arrive at a radiation detector response calibration.

In another implementation of the present disclosure, associating the patient exit fluence with a portion of the exit radiation measurement information can also include analysis of the heterogeneities inside the patient, and at least part of the radiation plan, to find a subset of the exit radiation measurement information for creating a list of suitable points to be used for arriving at the radiation detector response calibration. Using the suitable points, at least one grouping can be formed to arrive at a radiation detector response calibration for each grouping.

In one implementation of the present disclosure, determination of the patient entrance fluence during the time when the image was acquired is aided by finding the image start time and image end time. When these times are known, the patient entrance fluence may be determined through examination of the radiation treatment plan (e.g., beam intensities, collimator positions, etc.) at that same time.

While “times” are discussed herein, it should be understood that such may refer to typical chronological times (e.g., minutes or seconds), gantry angles, control points, delivered radiation, MLC positions, or any other parameter that may define when radiation detector data, or an EPID image, is acquired. For example, radiation treatment plans often describe the manner in which a radiation therapy device delivers treatment in terms of “control points.” A control point can be a collection of data points that define the status of the system including, for example, amount of radiation to be delivered, beam energy, collimator positions, gantry angle, gantry rotation direction, patient support position, etc.

FIG. 4 is a process flow diagram illustrating the exemplary process for determining the patient entrance fluence used in the process of FIG. 3. At 400, an approximate image capture time may be obtained, for example, from gantry angle information or the meter-set exposure values in DICOM tags of the EPID frames themselves. At 410, estimated collimator profiles are determined from at least a portion of the radiation treatment plan. These estimated collimator profiles represent the profile expected to be rendered by the radiation detector given an estimated image start time and image end time and the radiation treatment plan characteristics during that time period. At 420, estimated collimator profiles are compared to the actual measured collimator profile that was acquired by the radiation detector. In this comparison, it is not necessary to compare the entire profiles, for example, MLC profiles may be defined as an outline or boundary of the aperture formed by the leaves of the MLC. At 430, the image start time and image end time may be determined from the best match between the estimated collimator profiles and the measured collimator profile. In one implementation, estimated or measured collimator profiles can be also be derived from predicted radiation detector or EPID images.

At 440, patient entrance fluence may be determined by utilizing a portion of the radiation treatment plan and the image start time and image end time. For example, when the actual image start time and image end time are known, the relevant beam characteristics from that period of time (e.g., shape, dose rates, etc.) may be used to calculate the patient entrance fluence during the time when the radiation detector image was acquired.

FIG. 5 is a diagram illustrating an exemplary manner of searching for the image start time and image end time that produce a best match between an estimated collimator profile and the measured collimator profile that was acquired by the radiation detector. In one implementation, as illustrated in FIG. 5, the initial, approximate image capture time (e.g., from an EPID image's DICOM tag) is represented by angle A of gantry 140. In the example shown, control points 510 are illustrated as angle measures on an expanded view of the gantry rotation arc. The initial, approximate gantry angle A is shown by the central dashed line. The actual image start time 530 and actual image end time 532 are not known a priori, but are shown by the larger lines in the figure. Illustrating the iterative method of the current example, a first pairing of the approximate image start time and the approximate image end time is shown by the bracket 540. Upon comparing the estimated collimator profile for the period denoted by 540 to the measured collimator profile, the fit can be found to be rather poor. The searching algorithm can then determine a second pairing 550 of the approximate image start time and the approximate image end time. Again, the estimated collimator profile can be compared to the measured collimator profile, and the fit can be found to be improved over the first pairing. Similarly, a third pairing 560 can made that can be found to result in a best match between the estimated collimator profile and the measured collimator profile. The determination of the best match can be performed by iterative methods, multi-parameter error minimization, image recognition, distance minimization (between overlapping boundaries), etc.

In another aspect of the present disclosure, the system may calculate a difference between the measured collimator profile and the best matched estimated collimator profile. The difference can be represented by a convergence parameter, error value or any other metric that quantifies the comparison between the measured collimator profile and the estimated collimator profile. If the difference exceeds a predetermined value, a range of possible times for the image start time and the image end time used to calculate the estimated collimator profiles can be increased in an effort to arrive at a more accurate image start time and image end time. For example, if a large difference was due to a bad approximation of the endpoints of the initial search region, such an increase may be needed.

In another implementation there may be a common time base shared between radiation detector 180 and the radiation therapy control system 170. In yet another implementation, there may be a time base (in seconds) corresponding only to the control points 410 and the control point time base (in seconds) and a time base (also in seconds) can be synchronized, interpolated, etc. to obtain a best match between exit radiation measurement information for each image and the control point pairs. In a further implementation, the acquisition of images can be directly tied to coincide with control points 410. For example, when the radiation treatment plan 196 gets to a first starting control point, the radiation detector 180 begins acquiring data, continuing until a second ending control point is reached, at which time the radiation detector 180 stops acquiring data. In this way, the control points 410 can exactly define the image start time 430 and image end time 432. In another implementation especially useful for static collimator and gantry plans, the meter-set exposure, or any other measure of the amount of received radiation or duration of the acquisition, can be used to find the approximate starting and ending time of the radiation detector acquisition.

By comparing the calculated patient exit fluence based on the radiation detector signal, for example, the current or voltage detected at a given pixel of an EPID, to the patient exit fluence computed according to radiation treatment plan as described above, a calibrated radiation detector 180 can indicate a possible error in the delivery of radiation to the patient.

The radiation detector response calibration can include calibration data taken across many types of radiation treatment plans, patient anatomies, etc. A radiation detector response calibration may be expressed as a set of data points for each pixel of a radiation detector 180. A radiation detector response calibration can be built up over time to provide practitioners with calibration data, which can continue to statistically improve as more data is taken during calibrations. For a particular subset of radiation detector response calibration data, a radiation detector response calibration may be expressed as a radiation detector response calibration curve fit through selected data points. A wide variety of fitting methods and functions can be used for obtaining the fitted curve. Also, artificial neural networks can also be used to learn the calibration procedure or to fit the data.

The data points can be based on any of the parameters listed above and can also include pixel response data from the neighboring pixels if needed to improve statistics or take into account overlapping charge distribution or light diffusion through the phosphor. However, different pixels can be impacted at different angles of incidence by different spectra of radiation exiting the patient 130, which, among other things, alters the response of the pixels at different regions of the radiation detector. Therefore, not all data points from all pixels should be used to improve the statistics. Data points can also be grouped according to a particular time range, patient, plan type, treatment site, etc. Data points can be further grouped by, for example, field size, shape, patient distance from the radiation source, patient surface distance from the radiation detector, etc. A separate radiation detector response calibration curve can be obtained for each of these groups or a combination of these groups.

It is understood that the methods of the present disclosure may be utilized with many different types of radiation therapy plans such as arc-based, static field, etc. Moreover, implementations of the current subject matter can provide advantages such as automatic and ongoing calibration of radiation detectors as patients are treated, avoiding calibration drift through the use of continually updated calibration data. In addition, radiation detector calibration for dose may be determined during patient treatment, without the need for phantom calibration.

One or more aspects or features of the subject matter described herein can be realized in digital electronic circuitry, integrated circuitry, specially designed application specific integrated circuits (ASICs), field programmable gate arrays (FPGAs) computer hardware, artificial neural networks, firmware, software and/or combinations thereof. These various aspects or features can include implementation in one or more computer programs that are executable and/or interpretable on a programmable system including at least one programmable processor, which can be special or general purpose, coupled to receive data and instructions from and to transmit data and instructions to, a storage system, at least one input device and at least one output device. The programmable system or computing system may include clients and servers. A client and server are generally remote from each other and typically interact through a communication network. The relationship of client and server arises by virtue of computer programs running on the respective computers and having a client-server relationship to each other.

These computer programs, which can also be referred to programs, software, software applications, applications, components or code, include machine instructions for a programmable processor and can be implemented in a high-level procedural language, an object-oriented programming language, a functional programming language, a logical programming language and/or in assembly/machine language. As used herein, the term “machine-readable medium” refers to any computer program product, apparatus and/or device, such as for example magnetic discs, optical disks, memory and Programmable Logic Devices (PLDs), used to provide machine instructions and/or data to a programmable processor, including a machine-readable medium that receives machine instructions as a machine-readable signal. The term “machine-readable signal” refers to any signal used to provide machine instructions and/or data to a programmable processor. The machine-readable medium can store such machine instructions non-transitorily, such as for example as would a non-transient solid-state memory or a magnetic hard drive or any equivalent storage medium. The machine-readable medium can alternatively or additionally store such machine instructions in a transient manner, such as for example as would a processor cache or other random access memory associated with one or more physical processor cores.

To provide for interaction with a user, one or more aspects or features of the subject matter described herein can be implemented on a computer having a display device, such as for example a cathode ray tube (CRT) or a liquid crystal display (LCD) or a light emitting diode (LED) monitor for displaying information to the user and a keyboard and a pointing device, such as for example a mouse or a trackball, by which the user may provide input to the computer. Other kinds of devices can be used to provide for interaction with a user as well. For example, feedback provided to the user can be any form of sensory feedback, such as for example visual feedback, auditory feedback or tactile feedback; and input from the user may be received in any form, including, but not limited to, acoustic, speech or tactile input. Other possible input devices include, but are not limited to, touch screens or other touch-sensitive devices such as single or multi-point resistive or capacitive trackpads, voice recognition hardware and software, optical scanners, optical pointers, digital image capture devices and associated interpretation software and the like.

In the descriptions above and in the claims, phrases such as “at least one of” or “one or more of” may occur followed by a conjunctive list of elements or features. The term “and/or” may also occur in a list of two or more elements or features. Unless otherwise implicitly or explicitly contradicted by the context in which it used, such a phrase is intended to mean any of the listed elements or features individually or any of the recited elements or features in combination with any of the other recited elements or features. For example, the phrases “at least one of A and B;” “one or more of A and B;” and “A and/or B” are each intended to mean “A alone, B alone or A and B together.” A similar interpretation is also intended for lists including three or more items. For example, the phrases “at least one of A, B and C;” “one or more of A, B and C;” and “A, B and/or C” are each intended to mean “A alone, B alone, C alone, A and B together, A and C together, B and C together or A and B and C together.” Use of the term “based on,” above and in the claims is intended to mean, “based at least in part on,” such that an unrecited feature or element is also permissible.

The subject matter described herein can be embodied in systems, apparatus, methods and/or articles depending on the desired configuration. The implementations set forth in the foregoing description do not represent all implementations consistent with the subject matter described herein. Instead, they are merely some examples consistent with aspects related to the described subject matter. Although a few variations have been described in detail above, other modifications or additions are possible. In particular, further features and/or variations can be provided in addition to those set forth herein. For example, the implementations described above can be directed to various combinations and subcombinations of the disclosed features and/or combinations and subcombinations of several further features disclosed above. In addition, the logic flows depicted in the accompanying figures and/or described herein do not necessarily require the particular order shown or sequential order, to achieve desirable results. Other implementations may be within the scope of the following claims. 

What is claimed is:
 1. A computer program product comprising a non-transitory machine-readable medium storing instructions that, when executed by at least one programmable processor, cause the at least one programmable processor to perform operations comprising: receiving a radiation treatment plan; acquiring, by a radiation detector, exit radiation measurement information during delivery of patient treatment; receiving patient anatomy information; and determining a radiation detector response calibration utilizing at least the exit radiation measurement information, the patient anatomy information and at least a portion of the radiation treatment plan.
 2. The computer program product of claim 1, wherein the operations determining the radiation detector response calibration further comprise: determining a patient entrance fluence during a period of time when the exit radiation measurement information was acquired; determining a patient exit fluence, utilizing the patient entrance fluence and the patient anatomy information; and associating the patient exit fluence with at least a portion of the exit radiation measurement information to arrive at the radiation detector response calibration.
 3. The computer program product of claim 2, wherein associating the patient exit fluence with the at least the portion of the exit radiation measurement information further comprises: analyzing the heterogeneities inside the patient, and at least part of the radiation plan, to find a subset of the exit radiation measurement information for creating a list of suitable points to be used for arriving at the radiation detector response calibration; and forming at least one grouping from the list of suitable points to arrive at a radiation detector response calibration for each grouping.
 4. The computer program product of claim 2, wherein the operations determining the patient entrance fluence further comprise: determining an image start time and an image end time, wherein the image start time and image end time define the period of time when an image was acquired; and determining the patient entrance fluence utilizing the at least a portion of the radiation treatment plan and the image start time and image end time.
 5. The computer program product of claim 4 wherein the operations determining the image start time and the image end time further comprise: determining estimated collimator profiles from at least a portion of the radiation treatment plan; comparing the estimated collimator profiles to a measured collimator profile acquired by the radiation detector; and determining the image start time and image end time from the best match between the estimated collimator profiles and the measured collimator profile.
 6. The computer program product of claim 5 further comprising: determining a difference between the measured collimator profile and the best matched estimated collimator profile; and increasing a range of possible times for the image start time and the image end time used to determine the estimated collimator profiles if the difference exceeds a predetermined value, in an effort to arrive at a more accurate image start time and image end time.
 7. The computer program product of claim 6, wherein the radiation detector is an electronic portal imaging device.
 8. A method for calibrating a radiation detector comprising: receiving a radiation treatment plan; delivering a patient treatment according to the radiation treatment plan; acquiring, by the radiation detector, exit radiation measurement information during delivery of the patient treatment; receiving patient anatomy information; and determining a radiation detector response calibration utilizing at least the exit radiation measurement information, the patient anatomy information and at least a portion of the radiation treatment plan.
 9. The method of claim 8, wherein the determining of the radiation detector response calibration further comprises: determining a patient entrance fluence during a period of time when the exit radiation measurement information was acquired; determining a patient exit fluence, utilizing the patient entrance fluence and the patient anatomy information; and associating the patient exit fluence with at least a portion of the exit radiation measurement information to arrive at the radiation detector response calibration.
 10. The method of claim 9, wherein associating the patient exit fluence with the at least the portion of the exit radiation measurement information further comprises: analyzing the heterogeneities inside the patient, and at least part of the radiation plan, to find a subset of the exit radiation measurement information for creating a list of suitable points to be used for arriving at the radiation detector response calibration; and forming at least one grouping from the list of suitable points to arrive at a radiation detector response calibration for each grouping.
 11. The method of claim 9, wherein the determining the patient entrance fluence further comprises: determining an image start time and an image end time, wherein the image start time and image end time define the period of time when an image was acquired; and determining the patient entrance fluence utilizing the at least a portion of the radiation treatment plan and the image start time and image end time.
 12. The method of claim 11, wherein determining the image start time and the image end time further comprise: determining estimated collimator profiles from at least a portion of the radiation treatment plan; comparing the estimated collimator profiles to a measured collimator profile acquired by the radiation detector; and determining the image start time and image end time from the best match between the estimated collimator profiles and the measured collimator profile.
 13. The method of claim 12 further comprising: determining a difference between the measured collimator profile and the best matched estimated collimator profile; and increasing a range of possible times for the image start time and the image end time used to determine the estimated collimator profiles if the difference exceeds a predetermined value, in an effort to arrive at a more accurate image start time and image end time.
 14. The method of claim 13, wherein the radiation detector is an electronic portal imaging device.
 15. A system comprising: at least one processor; and at least one memory comprising instructions to cause the at least one processor to perform operations comprising: receiving a radiation treatment plan; delivering a patient treatment according to the radiation treatment plan; acquiring, by a radiation detector, exit radiation measurement information during delivery of the patient treatment; receiving patient anatomy information; and determining a radiation detector calibration utilizing at least the exit radiation measurement information, the patient anatomy information and at least a portion of the radiation treatment plan.
 16. The system of claim 15, wherein the operations determining the radiation detector response calibration further comprise: determining a patient entrance fluence during a period of time when the exit radiation measurement information was acquired; determining a patient exit fluence, utilizing the patient entrance fluence and the patient anatomy information; and associating the patient exit fluence with at least a portion of the exit radiation measurement information to arrive at the radiation detector response calibration.
 17. The system of claim 16, wherein associating the patient exit fluence with the at least the portion of the exit radiation measurement information further comprises: analyzing the heterogeneities inside the patient, and at least part of the radiation plan, to find a subset of the exit radiation measurement information for creating a list of suitable points to be used for arriving at the radiation detector response calibration; and forming at least one grouping from the list of suitable points to arrive at a radiation detector response calibration for each grouping.
 18. The system of claim 16, wherein the operations determining the patient entrance fluence further comprise: determining an image start time and an image end time, wherein the image start time and image end time define the period of time when an image was acquired; and determining the patient entrance fluence utilizing the at least a portion of the radiation treatment plan and the image start time and image end time.
 19. The system of claim 18 wherein the operations determining the image start time and the image end time further comprise: determining estimated collimator profiles from at least a portion of the radiation treatment plan; comparing the estimated collimator profiles to a measured collimator profile acquired by the radiation detector; and determining the image start time and image end time from the best match between the estimated collimator profiles and the measured collimator profile.
 20. The system of claim 19 wherein the operations further comprise: determining a difference between the measured collimator profile and the best matched estimated collimator profile; and increasing a range of possible times for the image start time and the image end time used to determine the estimated collimator profiles if the difference exceeds a predetermined value, in an effort to arrive at a more accurate image start time and image end time.
 21. The method of claim 20, wherein the radiation detector is an electronic portal imaging device. 